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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69300
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1b2
Name: solute carrier organic anion transporter family member 1B2
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1b2increases response to substanceISOSLCO1B3 (Homo sapiens)6480464CTDSLCO1B3 protein results in increased susceptibility to Okadaic AcidPMID:26134461
Slco1b2multiple interactionsISOSLCO1B3 (Homo sapiens)6480464CTDDehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Okadaic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]PMID:26134461
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