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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940 Species: Mus musculus RGD Object: Gene Symbol: Myc Name: myelocytomatosis oncogene

Acc ID: CHEBI:44616 Term: afimoxifene Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. CasRN: 68392-35-8 Chemical ID: MESH:C016601

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731438	6480464	CTD	methylselenic acid inhibits the reaction [4-hydroxytamoxifen results in increased expression of MYC mRNA]	PMID:16093440
increases expression	ISO	RGD:731438	6480464	CTD	4-hydroxytamoxifen results in increased expression of MYC mRNA	PMID:15528270 PMID:16093440
multiple interactions	ISO	RGD:731438	6480464	CTD	4-hydroxytamoxifen inhibits the reaction [Estrogens results in increased expression of MYC mRNA]	PMID:21233418
multiple interactions	ISO	RGD:731438	6480464	CTD	SU 6656 inhibits the reaction [4-hydroxytamoxifen results in increased expression of MYC mRNA]	PMID:15528270
increases expression	ISO	RGD:731438	6480464	CTD	4-hydroxytamoxifen results in increased expression of MYC mRNA	PMID:16093440 PMID:15528270