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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdkn1a Name: cyclin-dependent kinase inhibitor 1A

Acc ID: CHEBI:44185 Term: methotrexate Definition: A pteridine that has formula C20H22N8O5. CasRN: 59-05-2 Chemical ID: MESH:D008727

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735341	6480464	CTD	Methotrexate results in increased activity of and results in increased expression of CDKN1A protein TP53 affects the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein] nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein] TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]	PMID:21624110
increases expression	ISO	RGD:735341	6480464	CTD	Methotrexate results in increased expression of CDKN1A protein	PMID:17637740