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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1baffects response to substanceISOCDKN1B (Homo sapiens)6480464CTDCDKN1B protein affects the susceptibility to MethotrexatePMID:17217824
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDMethotrexate results in increased expression of CDKN1B mRNAPMID:22183962
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