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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k6affects response to substanceISOMAP2K6 (Homo sapiens)6480464CTDMAP2K6 protein affects the susceptibility to MethotrexatePMID:16217747
Map2k6decreases expressionISOMAP2K6 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of MAP2K6 mRNAPMID:19100307
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