Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1increases transportEXP 6480464CTDABCC1 protein results in increased transport of MethotrexatePMID:21737571
Abcc1affects response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 gene SNP affects the susceptibility to MethotrexatePMID:18256692
Abcc1affects transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the transport of MethotrexatePMID:15718312
Abcc1decreases expressionISOABCC1 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of ABCC1 mRNAPMID:23897011
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in decreased susceptibility to MethotrexatePMID:22095822
Abcc1increases exportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased export of MethotrexatePMID:27297967
Abcc1increases expressionISOABCC1 (Homo sapiens)6480464CTDMethotrexate results in increased expression of ABCC1 mRNA; Methotrexate results in increased expression of ABCC1 proteinPMID:24736981
Abcc1increases transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein mutant form results in increased transport of MethotrexatePMID:18336795
Go Back to source page   Continue to Ontology report