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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp7a1 Name: cytochrome P450, family 7, subfamily a, polypeptide 1

Acc ID: CHEBI:44185 Term: methotrexate Definition: A pteridine that has formula C20H22N8O5. CasRN: 59-05-2 Chemical ID: MESH:D008727

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Methotrexate results in decreased expression of CYP7A1 mRNA	PMID:15120968