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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Acc ID: CHEBI:43871
Term: fasudil
Definition: An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Chemical ID: MESH:C049347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arhgef11decreases expressionISOARHGEF11 (Homo sapiens)6480464CTDfasudil results in decreased expression of ARHGEF11 mRNA; fasudil results in decreased expression of ARHGEF11 proteinPMID:26172442
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