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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330 Species: Mus musculus RGD Object: Gene Symbol: Sod2 Name: superoxide dismutase 2, mitochondrial

Acc ID: CHEBI:4325 Term: dapsone Definition: Diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. CasRN: 80-08-0 Chemical ID: MESH:D003622

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3732	6480464	CTD	[SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone	PMID:19501153
multiple interactions	EXP		6480464	CTD	Dapsone inhibits the reaction [Paraquat results in decreased expression of SOD2 protein]	PMID:21765237