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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:42839
Term: 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
Definition: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Chemical ID: MESH:D011692
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1affects expressionEXP 6480464CTDPuromycin Aminonucleoside affects the expression of TGFB1 mRNAPMID:9527400
Tgfb1increases expressionEXP 6480464CTDPuromycin Aminonucleoside results in increased expression of TGFB1 mRNA; Puromycin Aminonucleoside results in increased expression of TGFB1 proteinPMID:12397044 PMID:14738908 PMID:19194550 PMID:19594554
Tgfb1multiple interactionsEXP 6480464CTDCelecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 protein]; Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]PMID:14738908 PMID:19194550
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