Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:42839
Term: 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
Definition: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Chemical ID: MESH:D011692
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDPuromycin Aminonucleoside results in increased expression of TP53 proteinPMID:14993511 PMID:15113391 PMID:16152783 PMID:17035936
Tp53multiple interactionsEXP 6480464CTD1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]PMID:14993511 PMID:17035936
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDPuromycin Aminonucleoside results in increased expression of TRP53 proteinPMID:15987750 PMID:17035936
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]PMID:15987750 PMID:17035936
Go Back to source page   Continue to Ontology report