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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621551 Species: Mus musculus RGD Object: Gene Symbol: Pmaip1 Name: phorbol-12-myristate-13-acetate-induced protein 1

Acc ID: CHEBI:42588 Term: 4-hydroxyphenyl retinamide Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. CasRN: 65646-68-6 Chemical ID: MESH:D017313

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1347426	6480464	CTD	ATF3 mutant form promotes the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] ATF3 mutant form promotes the reaction [Fenretinide results in increased expression of PMAIP1 protein] ATF4 mutant form inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] ATF4 mutant form inhibits the reaction [Fenretinide results in increased expression of PMAIP1 protein] Fenretinide promotes the reaction [ATF4 protein binds to PMAIP1 promoter]	PMID:20022965
multiple interactions	ISO	RGD:1347426	6480464	CTD	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] Cycloheximide inhibits the reaction [Fenretinide results in increased expression of PMAIP1 protein]	PMID:17216584
increases expression	ISO	RGD:1347426	6480464	CTD	Fenretinide results in increased expression of PMAIP1 protein Fenretinide results in increased expression of PMAIP1 mRNA	PMID:17216584 PMID:20022965
increases expression	ISO	RGD:1347426	6480464	CTD	Fenretinide results in increased expression of PMAIP1 protein Fenretinide results in increased expression of PMAIP1 mRNA	PMID:20022965 PMID:17216584