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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347509 Species: Homo sapiens RGD Object: Gene Symbol: CFLAR Name: CASP8 and FADD-like apoptosis regulator

Acc ID: CHEBI:42588 Term: 4-hydroxyphenyl retinamide Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. CasRN: 65646-68-6 Chemical ID: MESH:D017313

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Fenretinide inhibits the reaction [TNF protein results in increased expression of CFLAR protein]	PMID:16230421
decreases reaction	EXP		6480464	CTD	Fenretinide inhibits the reaction CFLAR protein	PMID:16230421