GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | affects expression | EXP | | 6480464 | CTD | Dexamethasone affects the expression of TGFB1 mRNA | PMID:18234956 | Tgfb1 | decreases activity | EXP | | 6480464 | CTD | Dexamethasone results in decreased activity of TGFB1 protein | PMID:11238185 | Tgfb1 | increases expression | EXP | | 6480464 | CTD | Dexamethasone results in increased expression of TGFB1 mRNA | PMID:35143883 | Tgfb1 | multiple interactions | EXP | | 6480464 | CTD | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SENP2 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of CTNNB1 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of PTPN1 protein]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of TGFB1 mRNA]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP7 protein]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP8 protein]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP9 protein]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; Dexamethasone inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]; PTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; PTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; PTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; PTPN1 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]; SENP2 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SENP2 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]] | PMID:10200566 PMID:10646786 PMID:15388240 PMID:16598785 PMID:26739621 PMID:29535048 PMID:9790906 | Tgfb1 | decreases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased expression of TGFB1 mRNA | PMID:16997883 PMID:19853017 | Tgfb1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased expression of TGFB1 mRNA; Dexamethasone results in decreased expression of TGFB1 protein | PMID:23210436 PMID:27884791 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of NLRC5 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of RELA protein]; [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB1 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Dexamethasone promotes the reaction [TGFB1 protein results in increased expression of SOX9 mRNA]; NLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; NLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NLRC5 protein inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]; NLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]]; NLRC5 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of RELA protein]]; SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]; TGFB1 protein inhibits the reaction [[Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; TGFB1 protein inhibits the reaction [[Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; TGFB1 protein inhibits the reaction [[Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] | PMID:16430859 PMID:16997883 PMID:17502159 PMID:20206132 PMID:26435214 PMID:26806094 PMID:33476690 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [TGFB1 protein results in increased expression of HDAC2 protein]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]; TGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; TGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG mRNA]; TGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORA mRNA]; TGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORC mRNA]; TGFB1 protein affects the reaction [[Dexamethasone co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in decreased expression of SP7 protein]; TGFB1 protein inhibits the reaction [[Dexamethasone co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in decreased expression of RUNX2 protein] | PMID:21619834 PMID:27396813 PMID:28300665 PMID:28694203 PMID:32324263 PMID:9543393 | | ||||||||||||||||||||||
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