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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrdecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of VDR mRNAPMID:20006981
Vdrincreases expressionISOVdr (Mus musculus)6480464CTDDexamethasone results in increased expression of VDR mRNAPMID:10694374 PMID:22733784
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDDexamethasone results in increased expression of VDR mRNAPMID:20006981
Vdrmultiple interactionsISOVdr (Mus musculus)6480464CTDDexamethasone promotes the reaction [1,25-dihydroxyvitamin D results in increased expression of VDR protein]PMID:11751517
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTD[Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of VDR proteinPMID:33836827
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