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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of IGF1 mRNA; Dexamethasone results in decreased expression of IGF1 proteinPMID:14618091 PMID:19853640 PMID:35148621
Igf1multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 mRNA]; Dexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 protein]PMID:10370016
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDDexamethasone results in decreased expression of IGF1 mRNAPMID:22733784
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of IGF1 mRNAPMID:19681914
Igf1increases expressionISOIgf1 (Mus musculus)6480464CTDDexamethasone results in increased expression of IGF1 mRNAPMID:23935943 PMID:30878453
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Dexamethasone co-treated with IGF1 protein] results in decreased expression of CKM protein; [Dexamethasone co-treated with IGF1 protein] results in increased expression of MYOG mRNA; [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGF1 mRNA; Dexamethasone promotes the reaction [IGF1 protein results in increased expression of CKM mRNA]; Dexamethasone promotes the reaction [IGF1 protein results in increased expression of MYH4 mRNA]; Dexamethasone promotes the reaction [IGF1 protein results in increased expression of MYH8 mRNA]; IGF1 protein inhibits the reaction [Dexamethasone results in decreased expression of and affects the localization of CDKN1A protein]; IGF1 protein inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Dexamethasone results in decreased stability of CDKN1A protein]; IGF1 protein promotes the reaction [Dexamethasone results in increased expression of MYH4 mRNA]; IGF1 protein promotes the reaction [Dexamethasone results in increased expression of MYH8 mRNA]; naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]PMID:16054899 PMID:22936724 PMID:28940008 PMID:30878453
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; [Dexamethasone co-treated with Sirolimus] results in decreased activity of IGF1 protein; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF1 mRNAPMID:15070696 PMID:28628672
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