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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4adecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of HNF4A mRNAPMID:20888898
Hnf4aincreases expressionEXP 6480464CTDDexamethasone results in increased expression of HNF4A mRNA; Dexamethasone results in increased expression of HNF4A proteinPMID:12837037 PMID:15965953
Hnf4aincreases activityISOHNF4A (Homo sapiens)6480464CTDDexamethasone results in increased activity of HNF4A proteinPMID:17978169
Hnf4aincreases expressionISOHNF4A (Homo sapiens)6480464CTDDexamethasone results in increased expression of HNF4A mRNA; Dexamethasone results in increased expression of HNF4A proteinPMID:17978169 PMID:19022236 PMID:20888898 PMID:24399729
Hnf4amultiple interactionsISOHNF4A (Homo sapiens)6480464CTDDexamethasone promotes the reaction [HNF4A protein binds to CYP2A6 promoter]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of HNF4A mRNA]PMID:17978169 PMID:19022236
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