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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP2E1 proteinPMID:11181506
Cyp2e1increases expressionEXP 6480464CTDDexamethasone results in increased expression of CYP2E1 mRNA; Dexamethasone results in increased expression of CYP2E1 proteinPMID:14618091 PMID:15965953 PMID:20501703 PMID:20607812
Cyp2e1multiple interactionsEXP 6480464CTD2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]; Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]; Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 protein]PMID:20501703
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDDexamethasone results in increased expression of CYP2E1 mRNAPMID:21041162
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