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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2092
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1decreases expressionISOAkr1b1 (Mus musculus)6480464CTDDexamethasone results in decreased expression of AKR1B1 proteinPMID:33567340
Akr1b1multiple interactionsISOAKR1B1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1B1 mRNAPMID:28628672
Akr1b1multiple interactionsISOAkr1b1 (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AKR1B1 mRNAPMID:24848799
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