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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347922 Species: Homo sapiens RGD Object: Gene Symbol: PCK1 Name: phosphoenolpyruvate carboxykinase 1 (soluble)

Acc ID: CHEBI:41879 Term: dexamethasone Definition: A fluorinated steroid that has formula C22H29FO5. CasRN: 50-02-2 Chemical ID: MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:3267	6480464	CTD	Dexamethasone results in increased expression of PCK1 mRNA	PMID:15919808
decreases expression	ISO	RGD:11062	6480464	CTD	Dexamethasone results in decreased expression of PCK1 mRNA	PMID:9518257
multiple interactions	ISO	RGD:11062	6480464	CTD	Cycloheximide inhibits the reaction [Dexamethasone results in decreased expression of PCK1 mRNA] Dexamethasone inhibits the reaction [Clofibrate results in increased expression of PCK1 mRNA] Dexamethasone inhibits the reaction [Isoproterenol results in increased expression of PCK1 mRNA] Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [rosiglitazone results in increased expression of PCK1 mRNA]] Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Clofibrate results in increased expression of PCK1 mRNA]] Dexamethasone inhibits the reaction [Oleic Acid results in increased expression of PCK1 mRNA]	PMID:9518257
multiple interactions	ISO	RGD:3267	6480464	CTD	[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA Hydrogen Peroxide inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA] sodium arsenite inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA]	PMID:8971075
increases expression	ISO	RGD:3267	6480464	CTD	Dexamethasone results in increased expression of PCK1 mRNA	PMID:15919808 PMID:23166830
increases expression	ISO	RGD:3267	6480464	CTD	Dexamethasone results in increased expression of PCK1 protein	PMID:23166830