GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a9 | affects metabolic processing | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein affects the metabolism of Tamoxifen; CYP3A5 protein polymorphism affects the metabolism of Tamoxifen | PMID:15596297 | Cyp3a9 | decreases activity | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in decreased activity of CYP3A5 protein | PMID:12419016 | Cyp3a9 | decreases expression | ISO | Cyp3a13 (Mus musculus) | 6480464 | CTD | Tamoxifen results in decreased expression of CYP3A13 mRNA | PMID:25123088 | Cyp3a9 | increases metabolic processing | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased metabolism of Tamoxifen | PMID:29285606 | Cyp3a9 | multiple interactions | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | [CYP3A5 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene | PMID:29285606 | | ||||||||||||||||||||||
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