• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494 Species: Rattus norvegicus RGD Object: Gene Symbol: Tert Name: telomerase reverse transcriptase

Acc ID: CHEBI:41774 Term: tamoxifen Definition: A stilbenoid that has formula C26H29NO. CasRN: 10540-29-1 Chemical ID: MESH:D013629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1353510	6480464	CTD	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Tamoxifen	PMID:18021753
multiple interactions	ISO	RGD:1353510	6480464	CTD	Tamoxifen inhibits the reaction [Estradiol results in increased activity of TERT protein] Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]	PMID:19561322
multiple interactions	ISO	RGD:1353510	6480464	CTD	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	PMID:16051634
multiple interactions	ISO	RGD:1353510	6480464	CTD	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	PMID:19501078
decreases expression	ISO	RGD:1353510	6480464	CTD	Tamoxifen results in decreased expression of TERT mRNA alternative form	PMID:19501078