GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | decreases expression | EXP | | 6480464 | CTD | Tamoxifen results in decreased expression of NR1I2 mRNA | PMID:27765674 | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased activity of NR1I2 protein | PMID:20041327 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [SR 12813 results in increased activity of NR1I2 protein] which results in decreased susceptibility to Tamoxifen; [Tamoxifen results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Tamoxifen results in increased expression of ABCB1 protein]; Tamoxifen binds to and results in increased activity of NR1I2 protein | PMID:16054614 PMID:18839173 PMID:19746521 PMID:20041327 PMID:33049310 | Nr1i2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | Tamoxifen binds to and results in increased activity of NR1I2 protein | PMID:33049310 | | ||||||||||||||||||||||
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