GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | decreases activity | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Tamoxifen results in decreased activity of CYP2E1 protein | PMID:18420780 | Cyp2e1 | decreases expression | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Tamoxifen results in decreased expression of CYP2E1 mRNA; Tamoxifen results in decreased expression of CYP2E1 protein | PMID:29974145 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 mRNA]; Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 protein]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] | PMID:29974145 | | ||||||||||||||||||||||
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