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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439 Species: Mus musculus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:41774 Term: tamoxifen Definition: A stilbenoid that has formula C26H29NO. CasRN: 10540-29-1 Chemical ID: MESH:D013629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:736765	6480464	CTD	Tamoxifen results in increased expression of CYP1B1 protein	PMID:19812351
decreases activity	ISO	RGD:736765	6480464	CTD	Tamoxifen results in decreased activity of CYP1B1 protein	PMID:12419016
decreases activity	EXP		6480464	CTD	Tamoxifen results in decreased activity of CYP1B1 protein	PMID:18420780