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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317190 Species: Homo sapiens RGD Object: Gene Symbol: POLE4 Name: polymerase (DNA-directed), epsilon 4, accessory subunit

Acc ID: CHEBI:41500 Term: 4-phenylbutyric acid Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. CasRN: 1821-12-1 Chemical ID: MESH:C075773

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	4-phenylbutyric acid results in decreased expression of POLE4 mRNA	PMID:14583596