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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:41470
Term: chymostatin
Definition: A peptide that has formula C31H41N7O6.
Chemical ID: MESH:C002101
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases response to substanceEXP 6480464CTDchymostatin results in decreased susceptibility to AGT protein modified formPMID:21602471
Agtmultiple interactionsEXP 6480464CTDEnalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]PMID:21602471
Agtdecreases expressionISOAgt (Mus musculus)6480464CTDchymostatin results in decreased expression of AGT protein modified formPMID:18300870
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTD[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein; chymostatin inhibits the reaction [KRAS protein mutant form results in increased expression of AGT protein]PMID:27649628 PMID:33380422
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