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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734049 Species: Homo sapiens RGD Object: Gene Symbol: COL1A1 Name: collagen, type I, alpha 1

Acc ID: CHEBI:41423 Term: celecoxib Definition: A pyrazole that has formula C17H14F3N3O2S. CasRN: 184007-95-2 Chemical ID: MESH:C105934

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:61817	6480464	CTD	celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]	PMID:16420518
decreases expression	ISO	RGD:61817	6480464	CTD	celecoxib results in decreased expression of COL1A1 mRNA	PMID:19201774