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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752 Species: Rattus norvegicus RGD Object: Gene Symbol: Spp1 Name: secreted phosphoprotein 1

Acc ID: CHEBI:41423 Term: celecoxib Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. CasRN: 184007-95-2 Chemical ID: MESH:C105934

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	celecoxib inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]	PMID:19356721