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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:4035
Term: cyhalothrin
Definition: A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C037304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityEXP 6480464CTDcyhalothrin results in increased activity of NR1I2 proteinPMID:19249324
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDcyhalothrin results in increased activity of NR1I2 protein; cyhalothrin results in increased activity of NR1I2 protein polymorphismPMID:19249324
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; CES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein]; cyhalothrin binds to and results in increased activity of NR1I2 proteinPMID:19249324 PMID:21115097 PMID:25028461
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDcyhalothrin binds to and results in increased activity of NR1I2 proteinPMID:21115097
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