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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315002 Species: Homo sapiens RGD Object: Gene Symbol: ISG20 Name: interferon stimulated exonuclease gene 20kDa

Acc ID: CHEBI:4031 Term: cyclosporin A Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. CasRN: 59865-13-3 Chemical ID: MESH:D016572

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Cyclosporine results in increased expression of ISG20 mRNA	PMID:20106945
decreases expression	ISO	RGD:1315003	6480464	CTD	Cyclosporine results in decreased expression of ISG20 mRNA	PMID:17942131
increases expression	EXP		6480464	CTD	Cyclosporine results in increased expression of ISG20 mRNA	PMID:20106945 PMID:21632981