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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdkn1a Name: cyclin-dependent kinase inhibitor 1A

Acc ID: CHEBI:40303 Term: lovastatin Definition: A fatty acid ester that has formula C24H36O5. CasRN: 75330-75-5 Chemical ID: MESH:D008148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735341	6480464	CTD	Lovastatin results in increased expression of CDKN1A protein	PMID:18034278
multiple interactions	ISO	RGD:732911	6480464	CTD	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]	PMID:22712078