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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347797 Species: Homo sapiens RGD Object: Gene Symbol: RHOA Name: ras homolog family member A

Acc ID: CHEBI:40303 Term: lovastatin Definition: A fatty acid ester that has formula C24H36O5. CasRN: 75330-75-5 Chemical ID: MESH:D008148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein] Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]	PMID:12933658
affects localization	EXP		6480464	CTD	Lovastatin affects the localization of RHOA protein	PMID:12933658
decreases prenylation	EXP		6480464	CTD	Lovastatin results in decreased prenylation of RHOA protein	PMID:16156861
multiple interactions	ISO	RGD:619921	6480464	CTD	Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein] geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]	PMID:9398081
affects localization	ISO	RGD:619921	6480464	CTD	Lovastatin affects the localization of RHOA protein	PMID:9398081
decreases prenylation	ISO	RGD:619921	6480464	CTD	Lovastatin results in decreased prenylation of RHOA protein	PMID:11178870
decreases expression	ISO	RGD:731060	6480464	CTD	Lovastatin results in decreased expression of RHOA mRNA	PMID:20493250