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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of NFE2L2 mRNA; Cyclophosphamide results in decreased expression of NFE2L2 proteinPMID:20038455 PMID:20433640 PMID:32456565
Nfe2l2increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of NFE2L2 mRNA; Cyclophosphamide results in increased expression of NFE2L2 proteinPMID:20038455 PMID:37419146
Nfe2l2multiple interactionsEXP 6480464CTD[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of NFE2L2 mRNA]PMID:20038455 PMID:20433640 PMID:32456565 PMID:37419146
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to CyclophosphamidePMID:27633142
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDCyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]PMID:27633142
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