GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | increases expression | EXP | | 6480464 | CTD | Cyclophosphamide results in increased expression of TP53 mRNA; Cyclophosphamide results in increased expression of TP53 protein | PMID:20038455 PMID:32197949 | Tp53 | increases mutagenesis | EXP | | 6480464 | CTD | Cyclophosphamide results in increased mutagenesis of TP53 exon | PMID:19227835 | Tp53 | multiple interactions | EXP | | 6480464 | CTD | astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein]; chlorophyllin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA] | PMID:19227835 PMID:20038455 PMID:32197949 | Tp53 | affects response to substance | ISO | Trp53 (Mus musculus) | 6480464 | CTD | TRP53 affects the susceptibility to Cyclophosphamide | PMID:10766175 | Tp53 | affects response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein affects the susceptibility to Cyclophosphamide | PMID:15182437 | Tp53 | increases activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Cyclophosphamide metabolite results in increased activity of TP53 protein | PMID:20655369 PMID:22010212 | Tp53 | increases mutagenesis | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Cyclophosphamide results in increased mutagenesis of TP53 exon | PMID:9610789 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein promotes the reaction [Methotrexate results in increased susceptibility to Cyclophosphamide metabolite] | PMID:22010212 | |
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