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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of TP53 mRNA; Cyclophosphamide results in increased expression of TP53 proteinPMID:20038455 PMID:32197949
Tp53increases mutagenesisEXP 6480464CTDCyclophosphamide results in increased mutagenesis of TP53 exonPMID:19227835
Tp53multiple interactionsEXP 6480464CTDastaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein]; chlorophyllin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA]PMID:19227835 PMID:20038455 PMID:32197949
Tp53affects response to substanceISOTrp53 (Mus musculus)6480464CTDTRP53 affects the susceptibility to CyclophosphamidePMID:10766175
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 protein affects the susceptibility to CyclophosphamidePMID:15182437
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDCyclophosphamide metabolite results in increased activity of TP53 proteinPMID:20655369 PMID:22010212
Tp53increases mutagenesisISOTP53 (Homo sapiens)6480464CTDCyclophosphamide results in increased mutagenesis of TP53 exonPMID:9610789
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDTP53 protein promotes the reaction [Methotrexate results in increased susceptibility to Cyclophosphamide metabolite]PMID:22010212
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