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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2448
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsl
Name: cathepsin L
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsldecreases expressionISOCtsl (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of CTSL mRNAPMID:30760223
Ctslincreases expressionISOCTSL (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of CTSL mRNAPMID:17403535
Ctslmultiple interactionsISOCtsl (Mus musculus)6480464CTD5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in decreased expression of CTSL mRNA]PMID:30760223
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