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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1affects response to substanceISOALDH1A1 (Homo sapiens)6480464CTDALDH1A1 protein affects the susceptibility to CyclophosphamidePMID:18854779
Aldh1a1decreases response to substanceISOALDH1A1 (Homo sapiens)6480464CTDALDH1A1 protein results in decreased susceptibility to CyclophosphamidePMID:12513786
Aldh1a1increases expressionISOALDH1A1 (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of ALDH1A1 mRNAPMID:17403535
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