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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3726
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smo
Name: smoothened, frizzled class receptor
Acc ID: CHEBI:4021
Term: Cyclopamine
Definition: A piperidine that has formula C27H41NO2.
Chemical ID: MESH:C000541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smomultiple interactionsEXP 6480464CTDcyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO protein]PMID:24388991 PMID:24464877
Smoincreases expressionISOSMO (Homo sapiens)6480464CTDcyclopamine results in increased expression of SMO mRNAPMID:26710974
Smomultiple interactionsISOSMO (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA]PMID:26710974
Smomultiple interactionsISOSmo (Mus musculus)6480464CTDcyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein]PMID:27481074
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