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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDValproic Acid results in decreased activity of GSR proteinPMID:28988495 PMID:34420476
Gsrmultiple interactionsEXP 6480464CTDVitamin U inhibits the reaction [Valproic Acid results in decreased activity of GSR protein]PMID:34420476
Gsraffects expressionISOGsr (Mus musculus)6480464CTDValproic Acid affects the expression of GSR mRNAPMID:17292431 PMID:17963808
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDValproic Acid results in increased expression of GSR mRNAPMID:23179753 PMID:28001369 PMID:29154799
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