• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620949 Species: Rattus norvegicus RGD Object: Gene Symbol: Ugt1a6 Name: UDP glucuronosyltransferase 1 family, polypeptide A6

Acc ID: CHEBI:39867 Term: valproic acid Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. CasRN: 99-66-1 Chemical ID: MESH:D014635

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects glucuronidation	ISO	RGD:1349499	6480464	CTD	UGT1A6 gene polymorphism affects the glucuronidation of Valproic Acid	PMID:15761113
increases glucuronidation	ISO	RGD:1349499	6480464	CTD	UGT1A6 protein results in increased glucuronidation of Valproic Acid	PMID:15761113
decreases expression	EXP		6480464	CTD	Valproic Acid results in decreased expression of UGT1A6 mRNA	PMID:17381134