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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of GFAP mRNA; Valproic Acid results in decreased expression of GFAP proteinPMID:18585900 PMID:22954530
Gfapincreases expressionEXP 6480464CTDValproic Acid results in increased expression of GFAP mRNA; Valproic Acid results in increased expression of GFAP proteinPMID:19360904
Gfapmultiple interactionsEXP 6480464CTDFinasteride inhibits the reaction [Valproic Acid results in increased expression of GFAP mRNA]; Finasteride inhibits the reaction [Valproic Acid results in increased expression of GFAP protein]PMID:19360904
Gfapdecreases expressionISOGfap (Mus musculus)6480464CTDValproic Acid results in decreased expression of GFAP mRNAPMID:30578912
Gfapincreases methylationISOGFAP (Homo sapiens)6480464CTDValproic Acid results in increased methylation of GFAP genePMID:29154799
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