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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2586
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2raffects expressionISOF2R (Homo sapiens)6480464CTDValproic Acid affects the expression of F2R mRNAPMID:25979313
F2rdecreases expressionISOF2r (Mus musculus)6480464CTDValproic Acid analog results in decreased expression of F2R mRNA; Valproic Acid results in decreased expression of F2R mRNAPMID:20546886 PMID:21427059
F2rincreases expressionISOF2R (Homo sapiens)6480464CTDValproic Acid results in increased expression of F2R mRNAPMID:24935251 PMID:27188386
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