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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2461 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp21a1 Name: cytochrome P450, family 21, subfamily a, polypeptide 1

Acc ID: CHEBI:39867 Term: valproic acid Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. CasRN: 99-66-1 Chemical ID: MESH:D014635

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1346271	6480464	CTD	Valproic Acid results in decreased expression of CYP21A2 mRNA	PMID:19566492