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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcdecreases activityISOSRC (Homo sapiens)6480464CTDCurcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC proteinPMID:33617879
Srcdecreases expressionISOSRC (Homo sapiens)6480464CTDCurcumin results in decreased expression of SRC proteinPMID:16959222
Srcmultiple interactionsISOSRC (Homo sapiens)6480464CTD[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC proteinPMID:33617879
Srcmultiple interactionsISOSrc (Mus musculus)6480464CTD[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]PMID:33617879
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