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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faslgdecreases expressionEXP 6480464CTDCurcumin results in decreased expression of FASLG mRNAPMID:10925121
Faslgdecreases expressionISOFASLG (Homo sapiens)6480464CTDCurcumin results in decreased expression of FASLG mRNAPMID:16101141
Faslgmultiple interactionsISOFASLG (Homo sapiens)6480464CTD[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]PMID:17351739 PMID:23452621 PMID:27430728
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