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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731 Species: Rattus norvegicus RGD Object: Gene Symbol: Sod1 Name: superoxide dismutase 1, soluble

Acc ID: CHEBI:3962 Term: curcumin Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. CasRN: 458-37-7 Chemical ID: MESH:D003474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein] Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA] Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein] Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]	PMID:19914224