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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5decreases activityEXP 6480464CTDCurcumin results in decreased activity of ALOX5 proteinPMID:16956363
Alox5multiple interactionsEXP 6480464CTD[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 proteinPMID:16956363
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