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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735269 Species: Homo sapiens RGD Object: Gene Symbol: DIO1 Name: deiodinase, iodothyronine, type I

Acc ID: CHEBI:39421 Term: perfluorooctane-1-sulfonic acid Definition: An organofluorine compound that has formula C8HF17O3S. CasRN: 1763-23-1 Chemical ID: MESH:C076994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:2504	6480464	CTD	perfluorooctane sulfonic acid affects the expression of DIO1 mRNA	PMID:19045937
decreases expression	ISO	RGD:2504	6480464	CTD	perfluorooctane sulfonic acid results in decreased expression of DIO1 mRNA	PMID:18692542 PMID:19162173
decreases expression	ISO	RGD:2504	6480464	CTD	perfluorooctane sulfonic acid results in decreased expression of DIO1 mRNA	PMID:19162173 PMID:18692542