GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 protein | PMID:26844784 | Nfe2l2 | decreases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of NFE2L2 mRNA | PMID:32790152 | Nfe2l2 | increases activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | perfluorooctane sulfonic acid results in increased activity of NFE2L2 protein | PMID:26548598 PMID:30114225 PMID:30203046 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNA | PMID:35337807 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNA; perfluorooctane sulfonic acid results in increased expression of NFE2L2 protein | PMID:26548598 PMID:33096110 PMID:36321694 | Nfe2l2 | increases response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 gene mutant form results in increased susceptibility to perfluorooctane sulfonic acid | PMID:33812015 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 protein | PMID:26844784 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [perfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNA]; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NFE2L2 mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of NFE2L2 mRNA; Calcitriol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [perfluorooctane sulfonic acid results in increased activity of CASP3 protein]; perfluorooctane sulfonic acid inhibits the reaction [NFE2L2 protein binds to NQO1 promoter] | PMID:26548598 PMID:32991729 PMID:33096110 PMID:33812015 PMID:36321694 PMID:36331819 | |
Go Back to source page | Continue to Ontology report |