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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP2C6V1 mRNAPMID:21723365
Cyp2c6decreases activityISOCYP2C19 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased activity of CYP2C19 proteinPMID:31809754 PMID:35121066
Cyp2c6decreases expressionISOCYP2C19 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of CYP2C19 mRNAPMID:31809754
Cyp2c6increases expressionISOCyp2c29 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP2C29 proteinPMID:32979393
Cyp2c6increases expressionISOCYP2C19 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP2C19 mRNAPMID:21723365
Cyp2c6multiple interactionsISOCyp2c29 (Mus musculus)6480464CTD[Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP2C29 mRNA; [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP2C29 protein; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2C29 mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of CYP2C29 protein; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CYP2C29 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of CYP2C29 mRNAPMID:32979393 PMID:32991729 PMID:33483757 PMID:36331819
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin]PMID:21964418
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